Endocrine Abstracts

Background: vitamin D has been associated with different beneficial effects on the immune system. The vitamin D activating (CYP2R1 and CYP27B1) and inactivating (CYP24A1) enzymes, including the vitamin D receptor (VDR) are expressed in several types of white blood cells (WBC). A range of studies have explored whether vitamin D positively affects risk of and severity of respiratory tract infections such as tuberculosis, influenza, cold and COVID-19.Object...

More than 90% of malignant testicular tumors arise in the germ cells and are denoted testicular germ cell tumors (TGCTs). TGCTs are one of the most common cancers among men between 15 to 40 years of age and arise from a common precursor cell, the germ cell neoplasia in situ (GCNIS), an arrested and transformed fetal gonocyte that become invasive after puberty. TGCTs are divided into seminomas and nonseminomas based on histology. Fortunately, TGTCs are highly sensitive to cispl...

Background: Studies have shown that the overall risk of cancer is not increased in Turner syndrome (TS). However, the pattern of cancer occurrence may be different than in the background population.Aim: To describe the cancer morbidity pattern in TS.Design: Nationwide epidemiological study using Danish registries on morbidity.Methods: 1,156 Females with TS diagnosed during 1960–2014 were identified using...

Introduction: Cyclic Cushing’s syndrome (CS) is a rare disorder, characterised by alternating periods of normo – and hypercortisolism.Case report: An 18-year-old young man was followed at the Department of Growth and Reproduction due to Klinefelter and received androgen replacement since the age of 12. As he was shifted to i.m. injections his liver enzymes increased and liver damage due to androgen replacement was suspected. A liver biopsy show...

In patients with adult growth hormone deficiency (AGHD), the dose of growth hormone (GH) replacement is individualised based on clinical outcome, insulin-like growth factor-I (IGF-I) levels and adverse reactions. The aim of this analysis was to characterise dose–IGFI–response for somapacitan, a long-acting reversible albumin-binding GH derivative, and to derive expected IGF-I levels for various starting doses. Somapacitan dose–IGF-I–response analysis wa...

Somapacitan is a long-acting growth hormone (GH) derivative designed for once-weekly subcutaneous administration. Correct assessment of insulin-like growth factor-I (IGF-I) levels is essential during treatment of GH deficiency (GHD) and must account for fluctuations over a dosing interval. We evaluated whether reliable estimates of weekly mean and peak IGF-I could be obtained from a single IGF-I sample. A population pharmacokinetic/pharmacodynamic model was available from phar...

Glucagon-like peptide-1 (GLP-1) is an incretine hormone with multiple actions besides control of glucose homeostasis. GLP-1 is known to cause natriuresis in humans but the effects on basic renal physiology are still partly unknown.This study therefore aimed to demonstrate the effects of GLP-1 on kidney hemodynamics, electrolyte handling, and the renin–angiotensin–aldosterone system in healthy men.Twelve healthy young male...

Diagnosis and management of infants and children with sex steroid disorders requires fast and simultaneous assessment of several sex steroid metabolites in serum at low concentrations and on small sample volumes. Therefore, we developed a sensitive and selective TurboFlow-LC-MS/MS method for quantification of DHEA, DHEAS, 17α-hydroxyprogesterone, Δ4-androstenedione and testosterone in serum from pre-pubertal children.Total run time was 10.75 mi...

Introduction: Vitamin D (VD) metabolism is active in normal testis, but lost during the malignant progression from carcinoma in situ (CIS) to overt germ cell tumors (TGCTs). CIS and TGCTs are often associated with intratubular deposition of hydroxyapatite (microlithiasis). Imbalance in FGF23 and PTH homeostasis may result in calcification of mesodermal-derived tissue, so we hypothesized that this mechanism may be involved in testicular microlithiasis. Here, we investi...

Introduction: There is concern that unintended environmental exposures to numerous chemicals, including bisphenol A (BPA), triclosan (TCS) and benzophenone-3 (BP-3), all of which can be detected in serum and urine, may have adverse endocrine effects on human reproduction. Less is known about the concentrations of these chemicals in other body fluids. Here we present data, which show that these three chemicals can also be present in seminal fluid of young men.<p class="abst...